Tere is the ideal nurse: sweet, smart and caring to her patients. She struggles to learn how to stand on her own, something which Tere Villanueva (Iza Calzado) has been doing since she was young.

But her husband's daughter from his first wife, Amanda dela Vega, is determined to bring her down by arranging that she inherits nothing but a nearly-bankrupt business. She married an old business tycoon and eventually became a widow. Marilou Cobarubbias (Ruffa Gutierrez) started as a simple girl who was trained to be a beauty queen. She is successful in her field and enjoys being in the spotlight but her success is not without intrigues and lawsuits, something which is not new to her star client Marilou. Her clients include high profile beauty queens and socialites such as Marilou Cobarrubias (Ruffa Gutierrez) and Betchay Magbutay-Cavendish (Carmi Martin). Cleo Carillo (Eula Valdes) is a very well-known cosmetic surgeon to celebrities. Seven women of different backgrounds, stories and personalities entwined in a colorful story of family, love and life - Dr. Continuing the tradition of national artist Ishmael Bernal's benchmark film Working Girls after 25 years, Working Girls of 2010 depicts the role of women in the new millennium.

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